Expert Guidance to Help You Understand Your Diagnosis, Treatment Options, and Recovery
Prostate Cancer Guide
Expert Guidance to Help You Understand Your Diagnosis, Treatment Options, and Recovery
Prostate Cancer Guide
A Personal Introduction from Professor Sooriakumaran
For many men, the first suspicion of prostate cancer brings uncertainty, worry and a lot of questions. Some
men are told they have a raised PSA. Others are advised to have an MRI scan or biopsy. Some have no symptoms
at all, but are concerned because of their age, family history or a recent health check.
At that point, clear information matters.
This guide has been created to help men and their families understand prostate cancer in a straightforward,
practical and balanced way. It explains what the prostate is, how prostate cancer is usually detected, what
tests may be recommended, and what treatment options may be available depending on the stage and nature of the
disease.
Prostate cancer is not one single situation. Some prostate cancers are slow-growing and may be suitable for
careful monitoring. Others require active treatment. The right decision depends on the individual patient, the
results of their investigations, their general health and their personal priorities.
Having treated many men with prostate cancer, I know that the period before and just after diagnosis can be
one of the most difficult parts of the journey. My aim with this guide is to give you a clearer understanding
of the process from initial concern through to diagnosis, treatment and follow-up care.
This information is not a replacement for a medical consultation, but it should help you feel better prepared
for the conversations you may need to have with your doctor or specialist.
Over the course of my career, I have found many men with prostate cancer, including those considering robotic
prostatectomy and other treatment options. One thing remains consistent: patients make better decisions when
they understand their condition properly and have the opportunity to ask the right questions.
I hope this guide gives you a useful starting point, reduces some of the confusion, and helps you take the
next step with more confidence.
Professor Prasanna Sooriakumaran Consultant Urological
Surgeon Prostate Clinic London
What is the prostate?
The prostate is a small gland that forms part of the male reproductive system. It sits just below the bladder
and surrounds the urethra, which is the tube that carries urine from the bladder out through the penis. In
younger adult men, the prostate is often described as being about the size of a walnut. However, the
prostate commonly becomes larger with age.
Although the prostate is small, its position means it can have a noticeable effect on urinary, sexual and
reproductive function. Because the urethra passes directly through the prostate, changes in the size or health
of the prostate can sometimes affect the flow of urine.
This is one reason why men with prostate enlargement, inflammation or prostate cancer may experience urinary
symptoms. However, it is important to understand that many men with early prostate cancer have no symptoms at
all.
The prostate sits below the bladder and surrounds the urethra, which is why prostate
conditions can sometimes affect urination.
Where is the prostate?
The prostate is located deep inside the pelvis. It sits:
below the bladder
in front of the rectum
around the upper part of the urethra
close to the seminal vesicles, which help produce semen
This position explains why doctors may examine the prostate through the rectum during a digital rectal
examination, also known as a DRE. It also explains why prostate problems can sometimes affect urination,
ejaculation or pelvic comfort.
The prostate is also close to important nerves and muscles involved in erectile function and urinary control.
This becomes important when discussing prostate cancer treatment, because treatments such as surgery or
radiotherapy may affect nearby structures.
What Does the Prostate Do?
The main role of the prostate is to help produce semen. Semen is the fluid that carries sperm during
ejaculation.
The prostate produces fluid that mixes with sperm from the testicles and fluid from the seminal vesicles.
This fluid helps support and protect sperm.
The prostate also contains muscle tissue that helps push semen into the urethra during ejaculation. This is
why some prostate conditions, and some prostate cancer treatments, can affect ejaculation or sexual function.
Role of the prostate
What it means
Semen production
The prostate adds fluid to semen, helping support and transport sperm.
Ejaculation support
Muscle tissue in the prostate helps move semen into the urethra.
Urinary flow influence
Because the urethra passes through the prostate, prostate changes can affect urine flow.
Reproductive function
The prostate contributes to semen, but it is not needed for urination itself.
Why Can the Prostate Affect Urination?
The prostate surrounds the urethra. If the prostate becomes enlarged, inflamed or affected by disease, it can
press on or narrow the urethra. This can make it harder for urine to pass normally.
Men may notice symptoms such as:
needing to urinate more often
waking at night to urinate
a weak urine stream
difficulty starting urination
stopping and starting while passing urine
dribbling after urination
feeling that the bladder has not emptied properly
needing to rush to the toilet
These symptoms are common as men get older and are often caused by benign prostate enlargement rather than
cancer. However, they should still be assessed properly, especially if they are new, worsening, or affecting
quality of life.
Why Urinary Symptoms Do Not Always Mean Prostate Cancer
Many men understandably worry that urinary symptoms may be a sign of prostate cancer. In reality, symptoms
such as a weak urine stream, waking at night to pass urine, urgency, or difficulty starting urination are
often caused by benign prostate enlargement rather than cancer.
Early prostate cancer often causes no symptoms. This is partly because many prostate cancers begin in the
outer part of the prostate, away from the urethra. Urinary symptoms may only appear if the cancer becomes
large enough to press on the urethra or has spread.
This means there are two important points to understand:
Situation
What it may mean
Urinary symptoms are present
Often caused by benign enlargement, inflammation or infection, but should still be assessed.
No urinary symptoms are present
Does not completely rule out prostate cancer, especially in men with risk factors.
This is why doctors look at the whole picture. Symptoms matter, but so do age, family history, ethnicity, PSA
level, examination findings, MRI results and overall health.
Does the Prostate Change With Age?
Yes. The prostate often grows larger as men get older. This is common and does not automatically mean
cancer.
A non-cancerous enlarged prostate is usually called benign prostate enlargement or benign prostatic
hyperplasia, often shortened to BPH.
Prostate enlargement can sometimes press on the urethra and affect urinary flow. This may lead to symptoms
such as getting up at night to pass urine, a weak stream, urgency, or feeling that the bladder has not emptied
properly.
However, prostate size alone does not tell the whole story. Some men with a large prostate have few symptoms.
Some men with a smaller prostate may have troublesome urinary symptoms. The effect depends on the position of
the enlargement, the bladder, the urethra and other individual factors.
Age is also one of the main risk factors for prostate cancer. For this reason, it is sensible to seek medical
advice if you develop new prostate-related symptoms or have concerns about your risk, particularly if you are
over 50, have a family history of prostate cancer, or are in a higher-risk group.
The prostate often becomes larger with age. Enlargement is common and does not automatically
mean cancer.
Key Patient Context: Prostate Enlargement and Age
Key point
Why it matters
Prostate enlargement becomes more common with age
This is one reason urinary symptoms are more common in older men.
Benign prostate enlargement is not prostate cancer
BPH is non-cancerous, although it can still cause troublesome symptoms.
Symptoms alone cannot reliably identify the cause
Similar symptoms can occur with enlargement, inflammation, infection or, less commonly, cancer.
A raised PSA is not automatically cancer
PSA can be raised for several reasons, including benign enlargement and inflammation.
No symptoms does not always mean no cancer
Early prostate cancer may not cause obvious urinary symptoms.
What Conditions Can Affect the Prostate?
Several different conditions can affect the prostate. They can sometimes cause similar symptoms, which is why
proper assessment matters.
Condition
What it means
Is it cancer?
Benign prostate enlargement
Non-cancerous growth of the prostate, common with age
No
Prostatitis
Inflammation or infection of the prostate
No
Prostate cancer
Cancer cells growing in the prostate gland
Yes
Raised PSA
A higher level of prostate specific antigen in the blood; this can have several causes
Not necessarily
A raised PSA does not automatically mean prostate cancer. PSA can rise because of prostate enlargement,
inflammation, infection, recent ejaculation, vigorous cycling, some medical procedures and other causes.
However, a raised PSA may need further investigation, depending on the level, age, symptoms, examination
findings and overall risk profile.
Why Understanding the Prostate Matters
Understanding where the prostate is and what it does can make prostate cancer testing and treatment easier to
understand.
PSA testing, MRI scans, biopsies and treatment options all relate back to the prostate's position near the
bladder, urethra, rectum, reproductive structures and surrounding nerves.
For example:
urinary symptoms may happen because the prostate surrounds the urethra
PSA is produced by prostate tissue, which is why it can be measured in a blood test
MRI scans are used to look for suspicious areas inside the prostate
biopsies take small samples of prostate tissue
surgery for prostate cancer usually involves removing the prostate gland
radiotherapy treats the prostate and sometimes surrounding areas, depending on the cancer stage
treatments may affect urination, erections or ejaculation because of the prostate's position near the
bladder, urethra, nerves and reproductive structures
This does not mean that every man will experience side effects after treatment. It does mean that treatment
decisions should be made carefully, with a clear understanding of the potential benefits and risks.
When Should You Seek Medical Advice?
You should speak to a GP or prostate specialist if you notice:
new or persistent urinary symptoms
blood in the urine
blood in the semen
pain when passing urine
unexplained pelvic discomfort
problems getting or keeping an erection
unexplained bone pain, weight loss or tiredness
concerns about your prostate cancer risk
You should also consider seeking advice if you have no symptoms but are worried because of your age, family
history, ethnicity, previous PSA result or general health concerns.
Many prostate cancers do not cause obvious symptoms in the early stages, so relying on symptoms alone is not
always enough.
Common Misconceptions About the Prostate
Misconception
Reality
"Urinary symptoms usually mean prostate cancer."
Most urinary symptoms in older men are caused by benign prostate enlargement, bladder issues,
inflammation or infection. However, symptoms should still be assessed.
"If I have no symptoms, I cannot have prostate cancer."
Early prostate cancer often causes no symptoms. Men with risk factors may still need advice or
testing.
"A raised PSA means I definitely have cancer."
PSA can be raised for several non-cancerous reasons. A raised PSA is a reason to investigate
further, not a diagnosis by itself.
"An enlarged prostate is the same as prostate cancer."
Benign prostate enlargement and prostate cancer are different conditions.
"A normal digital rectal examination rules out prostate cancer."
A DRE can provide useful information, but it cannot rule out prostate cancer on its own. PSA
testing, MRI and biopsy may still be needed depending on the situation.
Key Takeaways
The prostate is a small but important gland that helps produce semen and sits in a position that can affect
both urinary and sexual function. Enlargement, inflammation and prostate cancer can sometimes cause similar
symptoms, which is why proper assessment matters rather than assumptions based on symptoms alone. A raised PSA
does not automatically mean cancer, but it deserves careful interpretation. And because early prostate cancer
may cause no symptoms at all, men with risk factors or concerns should not wait for something to feel wrong
before seeking advice.
What Is Prostate Cancer?
Prostate cancer is cancer that starts in the prostate gland. The prostate is a small gland below the bladder
that helps produce semen and surrounds the urethra, the tube that carries urine out of the body.
Like all cancers, prostate cancer begins when cells start to grow and divide in an abnormal and uncontrolled
way. Over time, these cells can form a tumour inside the prostate. Some prostate cancers grow very slowly and
may never cause serious harm. Others can grow more quickly and may need active treatment.
This difference is important. A diagnosis of prostate cancer does not automatically mean that urgent
treatment is needed, but it does mean the cancer should be assessed carefully. The aim is to understand how
aggressive it appears to be, whether it is still within the prostate, and which treatment options are most
appropriate for the individual patient.
For many men, prostate cancer is first suspected after a raised PSA blood test, an abnormal prostate
examination, an MRI scan or a biopsy. Some men have urinary symptoms, but many men with early prostate cancer
have no symptoms at all.
Key Patient Context
Point
What it matters
Prostate cancer is one of the most common cancers in men in the UK
This is why awareness, risk assessment and appropriate testing matter, especially as men get older.
Early prostate cancer often has no symptoms
A man can feel well and still have prostate cancer, particularly in the early stages.
Not all prostate cancers behave the same way
Some may be suitable for active surveillance, while others need active treatment.
The most important question is not only "Is cancer present?"
Doctors also need to know how aggressive it is and whether it has spread beyond the prostate.
What Happens in Prostate Cancer?
The body is made up of cells. Normally, cells grow, divide and die in a controlled way. Cancer can develop
when this process goes wrong and cells continue to grow when they should not.
In prostate cancer, abnormal cells develop inside the prostate gland. These cells may form a small tumour. In
some men, the cancer grows slowly and remains within the prostate for many years. In others, the cancer may
grow more quickly, invade nearby tissues, or spread to other parts of the body.
When prostate cancer spreads, it most commonly spreads to nearby lymph nodes or bones. This is called
advanced or metastatic prostate cancer. However, many prostate cancers are found before they have spread,
especially when investigated after PSA testing or MRI scanning.
Where Does Prostate Cancer Usually Start?
Many prostate cancers begin in the outer part of the prostate, known as the peripheral zone. This matters
because the urethra passes through the central part of the prostate. A cancer growing in the outer part may
not press on the urethra early on.
This is one reason early prostate cancer often does not cause urinary symptoms. Urinary problems such as a
weak stream, waking at night to pass urine, urgency or difficulty starting urination are common in older men,
but they are often caused by benign prostate enlargement rather than prostate cancer.
That does not mean urinary symptoms should be ignored. New, persistent or worsening urinary symptoms should
be assessed. However, it also means that relying on symptoms alone is not a reliable way to rule out prostate
cancer.
Prostate Cancer Is Not One Single Situation
One of the most important things to understand is that prostate cancer varies widely from one man to another.
Some prostate cancers are low-risk and slow-growing. These may be monitored carefully with active
surveillance rather than treated immediately. Other prostate cancers are more aggressive and are more likely
to need treatment such as surgery, radiotherapy, hormone therapy, or a combination of treatments.
The right approach depends on several factors, including PSA level, MRI findings, biopsy results, Gleason
score or Grade Group, cancer stage, general health, age, life expectancy and personal priorities.
Type of situation
What it usually means
Possible approach
Low-risk localised prostate cancer
Cancer appears confined to the prostate and has features suggesting it may grow slowly.
Active surveillance may be suitable for some men.
Intermediate-risk prostate cancer
Cancer may still be confined to the prostate but has features that need closer consideration.
Options may include surgery, radiotherapy, focal therapy in selected cases, or surveillance in
carefully chosen patients.
High-risk localised or locally advanced prostate cancer
Cancer has features suggesting a higher chance of growth or spread, or may extend beyond the
prostate.
Treatment is usually recommended and may involve surgery, radiotherapy, hormone therapy or combined
treatment.
Metastatic prostate cancer
Cancer has spread to distant sites, commonly bones or distant lymph nodes.
Treatment usually focuses on controlling the cancer, relieving symptoms and maintaining quality of
life.
Localised, Locally Advanced and Metastatic Prostate Cancer
Doctors often describe prostate cancer according to how far it has spread. This helps guide treatment
decisions.
Term
What it means
Localised prostate cancer
The cancer appears to be contained within the prostate gland.
Locally advanced prostate cancer
The cancer has grown just outside the prostate or into nearby tissues.
Metastatic prostate cancer
The cancer has spread to distant parts of the body, such as bones or distant lymph nodes.
This classification is not based on one test alone. It usually depends on a combination of PSA blood test
results, MRI scan findings, biopsy results and, in some cases, additional imaging scans.
A man with localised prostate cancer may have several treatment options. A man with metastatic prostate
cancer usually needs a different treatment plan. This is why accurate diagnosis and staging are so important.
What Type of Cancer Is Prostate Cancer?
Most prostate cancers are adenocarcinomas. This means they start in the gland cells of the prostate, which
are the cells involved in producing prostate fluid.
There are rarer types of prostate cancer, including small cell prostate cancer, neuroendocrine prostate
cancer, transitional cell cancer and sarcoma. These are much less common and may behave differently from
typical prostate adenocarcinoma.
For most patients, the key issue is not simply the type of prostate cancer, but its risk category. This is
assessed using PSA, MRI, biopsy, Grade Group, stage and other clinical details.
How Is Prostate Cancer Usually Found?
Prostate cancer may be suspected in several ways. Some men have a raised PSA blood test. Some have an
abnormal prostate examination. Some have urinary symptoms that lead to further tests. Others are investigated
because they have a family history or are in a higher-risk group.
A diagnosis of prostate cancer is usually confirmed by a biopsy, where small samples of prostate tissue are
taken and examined under a microscope. Before biopsy, many men now have an MRI scan to look for suspicious
areas in the prostate and help guide the next steps.
Step
Purpose
Risk assessment
Considers age, symptoms, family history, ethnicity and general health.
PSA blood test
Measures prostate specific antigen, which can be raised in prostate cancer but also in non-cancerous
conditions.
Digital rectal examination
Allows a doctor to feel part of the prostate for enlargement, firmness or irregularity.
MRI scan
Looks for suspicious areas in the prostate and may help guide whether biopsy is needed.
Prostate biopsy
Confirms whether cancer cells are present and helps assess how aggressive they appear.
Staging tests, if needed
Help assess whether cancer has spread beyond the prostate.
What Doctors Need to Understand After Prostate Cancer Is Suspected
The aim of investigation is not only to find out whether prostate cancer is present. It is also to understand
the behaviour of the cancer and the safest, most appropriate treatment plan.
The main questions are:
Is prostate cancer present?
If cancer is present, how aggressive does it appear to be?
Is the cancer contained within the prostate?
Has it grown just outside the prostate?
Has it spread to lymph nodes, bones or other areas?
What are the likely benefits and risks of each treatment option?
What matters most to the patient, including cancer control, urinary function, erectile function, recovery
time and quality of life?
Common Misconceptions About Prostate Cancer
Misconception
Reality
"Prostate cancer always causes urinary symptoms."
Early prostate cancer often causes no symptoms. Urinary symptoms are more commonly caused by benign
prostate enlargement, but should still be assessed.
"A raised PSA means I definitely have prostate cancer."
PSA can be raised for several reasons, including enlargement, inflammation, infection, ejaculation,
cycling or recent procedures. A raised PSA may need further investigation, but it is not a diagnosis
by itself.
"All prostate cancers need immediate treatment."
Some low-risk prostate cancers can be safely monitored with active surveillance. Others need active
treatment. The decision depends on the individual cancer and the patient.
"Prostate cancer is always slow-growing."
Some prostate cancers are slow-growing, but others can be aggressive. This is why biopsy results,
Grade Group and staging are important.
Why Clear Information Matters
Prostate cancer decisions can be difficult because treatment is not only about removing or controlling
cancer. It is also about balancing cancer control with side effects, recovery and long-term quality of life.
For example, surgery and radiotherapy can both be appropriate treatments for suitable patients, but they have
different risks and recovery patterns. Active surveillance may be appropriate for some men with low-risk
disease, but may not be suitable for more aggressive cancer.
This is why a proper discussion with a prostate cancer specialist is important. Patients should understand
their diagnosis, their risk category, the realistic treatment options and the potential impact of each option
before making a decision.
Key Points
Key point
Simple explanation
Prostate cancer starts in the prostate gland
It develops when prostate cells grow abnormally and form cancer.
Early prostate cancer may cause no symptoms
Many men feel well when prostate cancer is first suspected or diagnosed.
Not all prostate cancers behave the same way
Some are slow-growing; others are more aggressive.
PSA is useful but not diagnostic by itself
A raised PSA can have several causes and usually needs interpretation alongside other findings.
Biopsy confirms the diagnosis
A biopsy shows whether cancer cells are present and helps assess aggressiveness.
Treatment should be individualised
The best option depends on the cancer, the patient's health and personal priorities.
Key Takeaways
Prostate cancer is not one single disease; it can range from slow-growing to aggressive.
A man can have early prostate cancer without any urinary symptoms.
The main purpose of testing is to understand whether cancer is present, how aggressive it is and whether
it has spread.
Some men may be suitable for active surveillance, while others may need active treatment.
Good treatment decisions depend on clear information, accurate staging and an honest discussion about
benefits, risks and quality of life.
Next in This Guide
How Common Is Prostate Cancer?
What Causes Prostate Cancer and Can It Be Prevented?
Risk Factors for Prostate Cancer
Symptoms of Prostate Cancer
How Do I Get Tested for Prostate Cancer?
How Common Is Prostate Cancer?
Prostate cancer is one of the most common cancers affecting men in the UK. It is also one of the cancers most
likely to raise difficult questions, because being common does not mean that every case behaves in the same
way.
Some prostate cancers are slow-growing and may never cause serious harm. Others are more aggressive and need
prompt treatment. For patients, the most useful question is not only, 'How common is prostate cancer?' It is
also, 'What does my personal risk look like, and what should I do about it?'
According to Prostate Cancer UK, prostate cancer is now the most commonly diagnosed cancer in the UK. The
charity reports that more than 64,000 men are diagnosed with prostate cancer each year, more than 12,000 men
die from the disease each year, and around 540,000 men are living with or after prostate cancer.
These numbers are important, but they need to be understood carefully. Prostate cancer is common,
particularly as men get older, but many men diagnosed with prostate cancer live for many years. Outcomes
depend on several factors, including the stage of the cancer, how aggressive it appears under the microscope,
PSA level, MRI findings, general health, treatment suitability and whether the cancer is found before it has
spread.
Key UK Statistics
The figures below give useful context for UK patients. Different organisations sometimes report slightly
different numbers because they may use different years, countries within the UK, registration methods or
statistical models. The overall message is consistent: prostate cancer is common, age-related, and a major
cause of cancer diagnosis in men.
Statistic
What the data says
What it means for patients
Annual UK diagnoses
Prostate Cancer UK reports more than 64,000 men diagnosed with prostate cancer each year.
Prostate cancer is not rare. A large number of men and families are affected every year.
England diagnoses in 2023
NHS England cancer registration statistics recorded 58,137 new prostate cancer diagnoses in England
in 2023, a 6% increase from 2022.
Recent official data shows high and rising numbers of diagnoses in England.
Lifetime risk
Prostate Cancer UK uses the headline estimate that around 1 in 8 men will be diagnosed with prostate
cancer in their lifetime.
A man's individual risk may be higher or lower depending on age, ethnicity, family history and
genetics.
Deaths each year
Prostate Cancer UK reports more than 12,000 deaths from prostate cancer each year.
Most men diagnosed with prostate cancer do not die from it, but the disease can be life-threatening,
especially when aggressive or diagnosed late.
Living with or after prostate cancer
Prostate Cancer UK estimates that around 540,000 men are living with or after prostate cancer.
Prostate cancer is often a long-term condition, with many men needing follow-up and ongoing support.
Long-term survival improvement
Cancer Research UK reports that ten-year prostate cancer survival has improved substantially since
the 1970s, from just over 3 in 10 to around 8 in 10 by 2018.
Survival has improved, but early and accurate diagnosis still matters.
Why Is Prostate Cancer So Common?
One of the main reasons prostate cancer is common is age. The prostate changes as men get older, and the risk
of prostate cancer rises significantly with age. Most prostate cancers are diagnosed in men over 50, and
Cancer Research UK reports that incidence rates are highest in men aged 75 to 79.
This does not mean younger men cannot develop prostate cancer. It means that the probability increases as men
move through midlife and older age. This is why discussions around risk often begin from the age of 50, or
earlier for men in higher-risk groups.
Another reason more cases are being recorded is that more men are being tested, investigated and diagnosed.
PSA blood testing, MRI scanning and greater public awareness can all increase the number of cancers detected.
Recent public awareness campaigns and high-profile diagnoses have also encouraged more men to ask about
prostate cancer risk.
An increase in recorded diagnoses does not automatically mean that prostate cancer is biologically becoming
more aggressive. It may partly reflect a growing and ageing population, increased testing, improved diagnostic
pathways and more men coming forward. However, it still matters because every diagnosis needs to be assessed
properly so that significant cancers are not missed and low-risk cancers are not overtreated.
Clinical Context: Common Does Not Always Mean Dangerous
The word 'common' can sound frightening, but it should not be interpreted as meaning that every prostate
cancer is immediately dangerous. Prostate cancer covers a wide spectrum of disease.
At one end are low-risk cancers that may grow so slowly that immediate treatment is not needed. These may be
monitored through active surveillance, which usually involves PSA testing, repeat MRI scans, clinical review
and sometimes further biopsies. At the other end are high-risk or advanced cancers that can grow more quickly
and may need treatment such as surgery, radiotherapy, hormone therapy, chemotherapy, newer systemic therapies,
or a combination of treatments.
This is why diagnosis is only the first step. Once prostate cancer is found, doctors need to understand the
risk category. That usually means looking at the PSA level, MRI scan, biopsy findings, Gleason score or Grade
Group, cancer stage and the patient's general health. Two men can both be diagnosed with prostate cancer but
need very different management plans.
Who Is More Likely to Develop Prostate Cancer?
Every man has some risk of prostate cancer, but the level of risk is not the same for everyone. Some factors
are strongly linked with a higher chance of developing the disease.
Did You Know?
Around 1 in 4 Black men will develop prostate cancer in their lifetime — approximately double the risk for men
overall. Black men are also more likely to be diagnosed at a younger age. If you are a Black man, it is worth
discussing prostate cancer risk with your GP from around age 45, even if you have no symptoms.
Risk factor
What is known
Practical meaning
Age
Risk increases as men get older. Prostate cancer mainly affects men over 50, with the highest
incidence rates in older age groups.
Men over 50 should be more aware of their risk, even if they feel well.
Black ethnicity
Prostate Cancer UK reports that about 1 in 4 Black men will get prostate cancer in their lifetime,
around double the headline risk for men overall.
Black men may need to discuss risk and PSA testing earlier, often from around age 45.
Family history
Risk is higher if a father, brother or close male relative has had prostate cancer, especially if
diagnosed at a younger age.
Family history should be mentioned to a GP or prostate specialist when discussing testing.
Inherited gene changes
Cancer Research UK notes that inherited BRCA2 gene changes can increase prostate cancer risk and may
be linked with faster-growing disease.
Men with known inherited cancer gene changes may need more individualised advice.
No symptoms
Early prostate cancer often causes no symptoms.
Absence of symptoms cannot be used as the only reassurance, especially in higher-risk men.
Is Prostate Cancer Becoming More Common?
Recent UK data suggests that recorded prostate cancer diagnoses have increased. NHS England cancer
registration statistics show that prostate cancer was the most diagnosed cancer in England in 2023, with
58,137 new diagnoses, a 6% increase from 2022. Prostate Cancer UK has also reported a sharp rise in UK
diagnoses over the last decade.
There are several possible reasons for this. The population is ageing, and prostate cancer is more common in
older men. More men are also aware of prostate cancer and are asking for PSA testing or specialist assessment.
Diagnostic pathways have changed, with MRI now playing a much larger role before biopsy. These factors can
increase the number of cancers found.
The Lancet Commission on prostate cancer, published in 2024, projected that global prostate cancer cases
could rise from 1.4 million in 2020 to 2.9 million by 2040. This projection is driven largely by ageing
populations worldwide and has important implications for healthcare planning. For individual patients in the
UK, it reinforces a clear message: prostate cancer will become an even more significant health issue in the
coming decades, making awareness, risk assessment and early diagnosis increasingly important.
For individual patients, this does not mean panic. It means awareness. Men should understand their personal
risk, know when to ask about PSA testing, and seek advice if they develop concerning symptoms or have risk
factors such as Black ethnicity, a strong family history or inherited cancer gene changes.
Why Early Diagnosis Matters
Prostate cancer is often more treatable when it is found before it has spread outside the prostate. Localised
prostate cancer may be managed in several ways, including active surveillance, robotic prostate surgery,
radiotherapy, brachytherapy or focal therapy in selected cases. Once prostate cancer has spread to distant
parts of the body, treatment usually focuses on controlling the disease rather than curing it.
This is why prevalence statistics matter. A common cancer that often causes no early symptoms creates a
difficult situation: many men feel perfectly well at the stage when testing may be most useful. Urinary
symptoms, when present, are often caused by benign prostate enlargement rather than cancer. That means
symptoms alone are not a reliable screening tool.
At the same time, testing has to be used sensibly. PSA testing can help identify men who need further
investigation, but PSA is not a cancer-specific test. It can be raised by benign prostate enlargement,
inflammation, infection, recent ejaculation, cycling and some medical procedures. A raised PSA is therefore
not a diagnosis; it is a reason to interpret the result carefully and consider whether further assessment is
needed.
Modern prostate cancer diagnosis increasingly relies on combining information rather than making decisions
from one result alone. PSA level, PSA density, clinical examination, MRI findings, biopsy results and personal
risk factors all help build a clearer picture.
Why There Is No Simple One-Size-Fits-All Screening Message
One of the most common questions is: if prostate cancer is so common, why is every man not automatically
screened? The answer is that prostate cancer testing involves a balance of benefits and harms.
Testing can help detect prostate cancer earlier, including cancers that may become dangerous if not treated.
However, it can also detect slow-growing cancers that may never have caused symptoms or shortened life. This
is called overdiagnosis. Overdiagnosis can lead to anxiety, repeated tests and, in some cases, treatment that
may not have been needed.
This is why UK practice places emphasis on informed decision-making. Men should be able to discuss the
possible benefits and limitations of PSA testing, especially if they are over 50 or in a higher-risk group.
For some men, testing may be sensible. For others, the decision may be less straightforward.
The key point is not that men should ignore prostate cancer risk. The key point is that testing should be
thoughtful, informed and interpreted by clinicians who understand prostate cancer diagnosis.
Common Misconceptions About How Common Prostate Cancer Is
Misconception
Reality
"If it is common, it must always be deadly."
No. Many men live for years after diagnosis, and survival has improved substantially. However,
aggressive or late-stage prostate cancer can be life-threatening.
"Only very old men get prostate cancer."
Risk rises with age, but prostate cancer can affect men in their 50s and sometimes younger,
especially in higher-risk groups.
"No symptoms means no prostate cancer."
Early prostate cancer often has no symptoms. Men can feel well even when prostate cancer is present.
"A raised PSA means cancer."
A raised PSA can have several causes. It needs careful interpretation and may lead to MRI or biopsy
if appropriate.
"All prostate cancers need immediate treatment."
Some low-risk cancers may be monitored with active surveillance. Others need active treatment
depending on risk and stage.
What This Means for Patients
The practical message is simple: prostate cancer is common enough that men should know their risk, but varied
enough that decisions should be individualised.
Men over 50 should consider discussing prostate cancer risk with their GP or a prostate specialist,
particularly if they are concerned about PSA testing or have urinary symptoms. Black men, men with a family
history of prostate cancer, and men with known inherited cancer gene changes may need to start that
conversation earlier.
Men should also understand that being diagnosed with prostate cancer does not automatically mean rushing into
treatment. The first priority is to understand the cancer properly. Is it low-risk or higher-risk? Is it
confined to the prostate? What does the MRI show? What does the biopsy show? What are the realistic treatment
options? What are the likely effects on urinary control, erections and quality of life?
Good care is not just about fighting prostate cancer. It is about identifying clinically significant prostate
cancer, avoiding unnecessary harm where possible, and choosing the right approach for the right patient.
Key Takeaways
Prostate cancer is one of the most common cancers in the UK, with more than 64,000 diagnoses and 12,000
deaths recorded each year — yet most men diagnosed with it will live for many years, and survival rates have
improved substantially over recent decades. Risk rises with age, but it is not evenly distributed: Black men,
men with a family history of prostate cancer, and those with inherited gene changes such as BRCA2 face a
meaningfully higher risk and should consider discussing testing earlier. Because early prostate cancer often
causes no symptoms at all, a raised PSA or specialist referral should be seen not as cause for alarm, but as
an opportunity to understand the picture properly. Some cancers will need treatment; others can be safely
monitored. The most important step is an accurate, individualised assessment — and the right clinician to help
interpret it.
What Causes Prostate Cancer and Can It Be Prevented?
There is rarely one single cause of prostate cancer. Like most cancers, it develops when changes occur inside
cells, allowing them to grow and divide in an abnormal way. Over time, these abnormal cells can form a tumour
in the prostate gland.
For most men, it is not possible to point to one clear reason why prostate cancer has developed. It is
usually the result of a combination of factors, including age, inherited risk, ethnicity, hormones, biological
processes and possibly lifestyle. Some of these factors cannot be changed. Others may be influenced by general
health, body weight and activity levels.
This distinction matters. A man should not assume that prostate cancer is his fault, or that he could
definitely have prevented it by eating differently or living differently. At the same time, understanding risk
factors can help men make sensible decisions about when to speak to a doctor, when to consider PSA testing,
and how to look after their wider health.
The most helpful way to think about this topic is not simply, 'What caused it?' but rather: 'Am I at higher
risk, and what can I do about that risk?'
Key Facts About Causes and Prevention
Question
Short answer
Do we know exactly what causes prostate cancer?
Not usually. Prostate cancer is usually linked to a combination of age, inherited risk, ethnicity,
hormones, biology and possibly lifestyle factors.
Can prostate cancer always be prevented?
No. There is no guaranteed way to prevent prostate cancer. Some important risk factors cannot be
changed.
Can lifestyle still matter?
Yes. Maintaining a healthy weight, staying active and eating a balanced diet may help reduce the
risk of aggressive or advanced prostate cancer and supports overall health.
Who is at higher risk?
Men over 50, Black men, men with a family history of prostate cancer, and men with certain inherited
gene changes may have a higher risk.
Does higher risk mean cancer is inevitable?
No. A higher risk means prostate cancer is more likely, but it does not mean a man will definitely
develop it.
What Actually Causes Prostate Cancer?
Cancer begins when the instructions inside cells become damaged or altered. These instructions are carried in
DNA. Normally, the body has systems to repair DNA damage or remove cells that are not behaving normally.
Cancer can develop when these systems fail and abnormal cells keep growing.
In prostate cancer, this happens within cells of the prostate gland. Most prostate cancers are
adenocarcinomas, meaning they start in glandular cells that help produce prostate fluid. The behaviour of
these cancer cells can vary widely. Some grow slowly over many years, while others are more aggressive and
more likely to spread.
Male hormones, especially androgens such as testosterone, are also involved in the biology of the prostate.
Prostate cells rely on androgen signalling to grow and function. This does not mean that normal testosterone
levels cause prostate cancer, but it helps explain why hormone therapy can be used to treat some prostate
cancers by reducing or blocking androgen activity.
In practical terms, most men will never know the exact biological trigger that started their prostate cancer.
What doctors can assess more reliably is the man's risk profile: PSA level, MRI findings, biopsy result, Grade
Group and stage. These details are far more useful for making decisions than trying to identify one single
cause.
Risk Factors You Cannot Change
Some of the strongest prostate cancer risk factors are not lifestyle choices. They are related to age,
ancestry, family history and inherited genes.
Risk factor
What it means for patients
Age
Risk increases as men get older. The NHS says prostate cancer mainly affects men over 50. Prostate
Cancer UK says men at higher risk may need to think about risk from age 45.
Black ethnicity
Black men have a higher lifetime risk of prostate cancer. Prostate Cancer UK states that about 1 in
4 Black men in the UK will get prostate cancer during their lifetime.
Family history
Having a father or brother with prostate cancer increases risk. Prostate Cancer UK states that a man
is around two and a half times more likely to get prostate cancer if his father or brother has had it.
Inherited gene changes
Some inherited gene changes, especially BRCA2, can increase prostate cancer risk. Cancer Research UK
and the NHS both highlight inherited genes as part of the risk picture.
Strong family history of linked cancers
A family history of prostate, breast, ovarian or pancreatic cancer, especially at a younger age, may
suggest an inherited genetic risk.
Age and Prostate Cancer Risk
Age is one of the most important prostate cancer risk factors. Prostate cancer can occur in younger men, but
it is much less common before the age of 50 unless there are additional risk factors such as a family history
or an inherited gene change.
The reason age matters is that cell changes can accumulate over time. As men get older, the prostate has had
more years of exposure to hormonal, genetic and biological changes. This does not mean every older man will
develop prostate cancer, but it does mean risk rises with age.
This is why conversations about PSA testing often begin around age 50 for men at average risk, and earlier
for some men at higher risk. A man's age should always be considered alongside his family history, ethnicity,
symptoms and personal concerns.
Family History and Genetic Risk
Family history is important because some prostate cancers are influenced by inherited genes. According to
Cancer Research UK, inherited factors are estimated to explain around 5 to 9% of prostate cancers. That does
not mean family history is directly inherited, but it does mean family history should be taken seriously.
Risk may be higher if a close male relative, such as a father or brother, has had prostate cancer. Risk may
be higher still if more than one close relative has been affected, or if relatives were diagnosed at a younger
age. A family history of breast, ovarian or pancreatic cancers may also be relevant because some of these
cancers can be linked through inherited gene changes such as BRCA2.
A BRCA2 gene change does not mean a man will definitely develop prostate cancer. However, it can increase
risk and may be associated with more aggressive disease. In May 2026, following a full evidence review, the UK
National Screening Committee published its recommendation for targeted prostate cancer screening for a
specific high-risk group — a recommendation formally accepted by the UK Government on 2 June 2026.
UK Clinical Update — New Prostate Cancer Screening Recommendation (May 2026)
Following a 2023–2026 evidence review, the UK National Screening Committee (UK NSC) recommended targeted
prostate cancer screening — a recommendation formally accepted by the UK Government on 2 June 2026. The
programme applies to: Men aged 45 to 61 who have a confirmed pathogenic BRCA2 variant AND a family history of
prostate cancer. These men will be offered PSA testing every two years. Rollout in England is expected to
begin in 2027. The UK NSC did not recommend screening for the general population, or for men with a family
history of prostate cancer alone without a confirmed BRCA2 variant. For Black men, the committee noted ongoing
uncertainty about whether screening would cause more benefits than harms, and confirmed it will work closely
with UK researchers — including the TRANSFORM trial — to address this. The next review is estimated for 2029
to 2030.
Men who are worried about a strong family history should discuss this with a GP, urologist or genetics
specialist. Genetic testing is not needed for everyone, but it may be considered when the family pattern
suggests an inherited cancer risk.
Ethnicity and Prostate Cancer Risk
Ethnicity is another important risk factor. Black men are more likely to develop prostate cancer than men
from other ethnic groups, and may also be diagnosed at a younger age. Prostate Cancer UK states that about 1
in 4 Black men in the UK will get prostate cancer during their lifetime, compared with about 1 in 8 men
overall.
The reasons for this increased risk are not fully understood. Genetics may play a role, but access to
healthcare and evidence review of ethnic differences in how early cancer is detected may also matter. It is
important not to reduce this risk to one simple explanation.
For patients, the practical message is clear: Black men should be aware of their higher risk and should
consider speaking to a GP or prostate specialist from the age of 45, or earlier if they have symptoms or a
strong family history.
The 2026 UK NSC review acknowledged that, for Black men, there is ongoing uncertainty about whether the
benefits of screening would outweigh the harms. The TRANSFORM trial — a major UK research programme — is
actively working to generate the evidence needed to resolve this uncertainty, and the UK NSC has confirmed it
will use findings from TRANSFORM to inform future screening decisions. This is an area where guidance is
expected to evolve.
Can Lifestyle Affect Prostate Cancer Risk?
Lifestyle is more complicated. There is no single diet, supplement or exercise routine that can guarantee
protection from prostate cancer. However, lifestyle may influence the risk of more aggressive or advanced
disease, and it also affects general health, treatment fitness and recovery.
The World Cancer Research Fund's evidence review on diet, nutrition, physical activity and prostate cancer
found that being overweight or obese is linked to an increase in the risk of advanced prostate cancer.
Prostate Cancer UK also advises that a healthy diet and regular exercise are important for maintaining a
healthy weight, which may help lower the risk of aggressive or advanced prostate cancer.
This does not mean that every man who is overweight will develop prostate cancer, or that a man of healthy
weight cannot develop prostate cancer. It means body weight is one of the few potentially modifiable factors
that may influence the risk of more serious prostate cancer.
Action
Why it may help
Maintain a healthy weight
Excess body fat is linked with a higher risk of advanced prostate cancer and can also affect general
health, diabetes risk, heart health and treatment fitness.
Stay physically active
Regular activity supports weight control, cardiovascular fitness, energy levels and recovery from
treatment. It may also help reduce the risk of aggressive or advanced disease.
Eat a balanced diet
A diet built around vegetables, fruit, wholegrains, pulses, healthy protein sources and limited
highly processed foods supports overall health.
Avoid relying on supplements as prevention
There is no proven supplement that reliably prevents prostate cancer. Supplements can also interact
with medicines or cause harm if taken inappropriately.
Do not smoke
Smoking is not usually presented as a main cause of prostate cancer, but stopping smoking reduces
the risk of many serious diseases and improves surgical and general health outcomes.
Know your personal risk
Early conversations are especially important for men over 50, Black men, and men with a family
history or known inherited gene change.
Can Prostate Cancer Be Prevented?
There is no guaranteed way to prevent prostate cancer. This is because some of the most important risk
factors, such as age, ethnicity and inherited genes, cannot be changed.
That can be frustrating, but it is also important. Men should not blame themselves if they develop cancer.
Prostate cancer is common, and many men who develop it have lived healthy lives.
Prevention should therefore be understood in a realistic way. The aim is not to promise that prostate cancer
can be avoided completely. The aim is to reduce avoidable risks where possible, support general health, and
identify higher-risk men early enough for sensible testing and discussion.
For many men, the most practical steps are to keep a healthy weight, stay active, eat a balanced diet,
understand their family history, and seek advice if they are in a higher-risk group. These steps may not
prevent every case, but they can improve overall health and may reduce the risk of advanced or aggressive
disease.
Prevention Is Not the Same as Early Detection
One common misunderstanding is to confuse prevention with early detection. Prevention means reducing the
chance of developing a disease in the first place. Early detection means finding a disease at an earlier
stage, when treatment may be more effective.
PSA testing, MRI scanning and biopsy do not prevent prostate cancer. They help assess whether cancer may
already be present and how concerning it appears to be. This distinction matters because a man can do
everything right and still develop prostate cancer, and a man can have no symptoms but still have early
disease.
In the UK, there is not a universal prostate cancer screening programme for all men. The 2026 UK NSC review
concluded that population-wide screening is more likely to cause harm than good, primarily because of the
risks of overdiagnosis and unnecessary treatment — including incontinence and erectile dysfunction in men who
may not have needed intervention. However, men can still speak to a GP about PSA testing, especially if they
are over 50 or at higher risk. The decision should be informed and individual.
Does Diet Cause Prostate Cancer?
There is no good evidence that one ordinary food directly causes prostate cancer in a simple way. Claims that
a single food either causes or prevents prostate cancer are usually too simplistic.
Research into diet and prostate cancer is difficult because people eat complex diets over many years, and
many factors influence cancer. For example, diet, body weight, physical activity, alcohol intake, smoking,
social factors and access to healthcare can all interact.
The safest patient message is that a balanced diet supports overall health and weight management. It should
not be sold as a guaranteed way to prevent prostate cancer. Men should be cautious about extreme diets,
miracle foods, high-dose supplements, or online claims that promise cancer prevention.
Common Misconceptions About Causes and Prevention
Misconception
Reality
"I must have done something to cause my prostate cancer."
Most men cannot identify one clear cause. Age, inherited risk, ethnicity and biology often matter
more than anything a patient has done.
"If I eat well, I cannot get prostate cancer."
A healthy lifestyle may reduce some risks and support overall health, but it cannot guarantee
prevention.
"Prostate cancer is always inherited."
Most prostate cancer is not directly inherited, although family history and certain gene changes can
increase risk.
"Only older men need to think about prostate cancer."
Risk rises with age, but Black men and men with a strong family history may need to think about risk
from age 45.
"Supplements can prevent prostate cancer."
No supplement has been proven to reliably prevent prostate cancer. Some supplements may be
unnecessary or harmful if taken in high doses.
"A PSA test prevents prostate cancer."
A PSA test does not prevent prostate cancer. It can help identify men who may need further
assessment.
When Should You Think About Your Risk?
It is sensible to think about prostate cancer risk if you are over 50, or over 45 and Black, or over 45 with
a family history of prostate cancer. You should also seek advice if you have urinary symptoms, blood in the
urine or semen, unexplained pelvic discomfort, new erectile problems, unexplained weight loss, bone pain, or
any concern that something has changed.
Men with a strong family history of prostate, breast, ovarian or pancreatic cancer should also consider
discussing risk with a doctor, particularly if relatives were diagnosed at younger ages. In some situations, a
genetics referral may be appropriate. Men with a confirmed BRCA2 variant and a relevant family history should
ask specifically about the new targeted screening programme and what it means for them.
The right approach depends on the individual. Some men may need reassurance and monitoring. Others will
benefit from discussion, PSA testing, MRI screening or specialist assessment. The important point is that risk
should be discussed early enough for informed decisions, rather than waiting for symptoms to become severe.
Key Takeaways
Prostate cancer rarely has one identifiable cause — for most men it results from a combination of age,
inherited risk, ethnicity and biology rather than anything they have done. The strongest risk factors are ones
that cannot be changed: being over 50, being a Black man, having a family history of prostate cancer, or
carrying an inherited BRCA2 gene change. In May 2026, following a full evidence review, the UK NSC recommended
targeted PSA screening every two years for men aged 45 to 61 with a confirmed BRCA2 variant and a relevant
family history — a recommendation formally accepted by the UK Government in June 2026, with rollout in England
expected from 2027. For Black men, the evidence on screening remains under active investigation through the
TRANSFORM trial, and guidance in this area is expected to evolve. Lifestyle cannot guarantee prevention, but
maintaining a healthy weight, staying active and eating well may reduce the risk of more aggressive disease
and supports overall health and treatment fitness. The most important step for any man is to understand his
personal risk — and to have that conversation early enough to act on it.
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